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Oct 10, 2021; Kansas City, Missouri, USA; Kansas City Chiefs quarterback Patrick Mahomes (15) scrambles from Buffalo Bills defensive end Mario Addison (97) during the second half at GEHA Field at Arrowhead Stadium. Mandatory Credit: Jay Biggerstaff-USA TODAY Sports

The Kansas City Chiefs will visit the Arizona Cardinals to kick off the 2022 season and their quest to return to the Super Bowl.

The NFL released its regular season schedule Thursday. Kansas City has a quick turnaround after Week 1's Sunday game on Sept. 11, hosting the division rival Los Angeles Chargers four days later for Thursday Night Football.

Other highlights include an Oct. 2 visit to Tampa Bay and longtime rival Tom Brady for Sunday Night Football; a Week 5 Monday night game vs. the Las Vegas Raiders; hosting fellow AFC frontrunner Tennessee for Sunday Night Football on Nov. 6; and the regular season finale on Jan. 7 or Jan 8. at Las Vegas.

Kansas City Chiefs 2022 Schedule:

Sept. 11 at Arizona, 3:25 p.m. (CBS)

Sept. 15 L.A. Chargers (Thu), 7:15 p.m. (Prime Video)

Sept. 25 at Indianapolis, 12 p.m. (CBS)

Oct. 2 at Tampa Bay, 7:20 p.m. (NBC)

Oct. 10 Las Vegas (Mon), 7:15 p.m. (ESPN)

Oct. 16 Buffalo, 3:25 p.m. (CBS)

Oct. 23 at San Francisco, 3:25 p.m. (FOX)

Oct. 30 BYE

Nov. 6 Tennessee, 7:20 p.m. (NBC*)

Nov. 13 Jacksonville, 12 p.m. (CBS)

Nov. 20 at L.A. Chargers, 3:25 p.m.(CBS)

Nov. 27 L.A. Rams, 3:25 p.m. (FOX)

Dec. 4 at Cincinnati, 3:25 p.m. (CBS)

Dec. 11 at Denver, 7:20 p.m. (NBC*)

Dec. 18 at Houston, 12 p.m. (CBS)

Dec. 24 Seattle (Sat), 12 p.m. (FOX)

Jan. 1 Denver, 12 p.m. (CBS)

Jan. 7/8 at Las Vegas, TBD TBD

* - Sunday night games in Weeks 5-17 subject to change; Week 18 game TBD.